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Abstract
The work is devoted to the study of the effect of a biostimulator and its compounds with zinc on spontaneous, PHA-induced blast transformation of T-lymphocytes in patients with chronic viral hepatitis B, as well as on the cytotoxic activity of natural killers in colon cancer, and healthy donors in the in vitro system. The results showed that the biostimulator has a moderate regulatory effect on spontaneous blast transformation of lymphocytes in the in vitro system. The costimulating effect of the biostimulator of the PHA-induced blast transformation of T-lymphocytes was revealed. A significant increase in the membranotoxic function of natural killer cells in relation to K-562 target cells was found under the influence of a biostimulator after preliminary incubation of the drug with effector cells. The biological efficiency of splenic peptides increased after the addition of zinc ions to them.
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