The effect of binder on the pharmaceutical tablets capping tendency

Abstract

The advancements and the innovations in the tablet presses have increased tablet failures that the most frequent is capping. The purpose of this paper was to examine the influence of binder in the mechanical behaviour of Trimebutine maleate tablet and to emphasise the power of its effect in capping tendency. Thus, we have developed in a first time two formulas of tablets which differ by the nature of their binder (gelatine and povidone). Then, we have carried out a comparative study of the compressional behaviour of the granules obtained by adopting the uniaxial compression technique followed by the Brazilian test. This study showed that data obtained from uniaxial compression and Brazilian test are correlated to mechanical materials properties of pharmaceutical mixtures and revealed that changing the nature of binder has a considerable effect in the mechanical behaviour of tablets and capping tendency.