Abstract
The response of hepatosplanchnic and other regional blood flows to CBD ligation has been studied after 1 and 2 weeks of biliary obstruction by the fractional distribution of differently labeled 25-μ carbonized microspheres injected into the left atrium. After 1 week of biliary obstruction, there was a generalized increased in effective liver blood flow and its hepatic arterial and portal venous components. The increase in the latter reflected an increase in arterial inflow to all the individual splanchnic viscera which was least in the colon. By 2 weeks, these changes had essentially returned to preoperative levels, with the exception of splenic flow. Coincident with these changes was an apparent increase in systemic arteriovenous shunting, the site of which was not determined. Possible causes underlying this early hepatosplanchnic response to biliary obstruction are discussed.
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