Abstract
While several studies have indicated a major role of the ?-arrestin family in the development of several types of cancer, little to no information is available on its influence in malignant gliomas.
 In our study we transfected an established high-grade glioma cell line, 11 HGG with a ?-1 arrestin plasmid in order to observe how ?-1 overexpression influences proliferation and response to standard of care treatment. After 24h, the transfected cells presented a drop in proliferation when compared to untransfected cells. In terms of treatment response, transfected cells presented a markedly elevated cytotoxic effect when compared to untransfected cells. However, after 48h and 72h transfected cells presented only a minor increase in proliferation while treatments responses to TMZ were modestly influenced by ?-1 arrestin overexpression.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
