The Effect of Barrier Gel and Free Fat Graft on the Formation of Epidural Fibrosis in the Laminectomy Model

Abstract

Introduction: This study aims to compare the efficacy of ADCON-L and free fat graft used to prevent epidural fibrosis in the experimental laminectomy model in rabbits. Materials and Methods: Thirty adult male New Zealand-type white rabbits weighing 2500-3000 grams were used. Three groups of ten were formed. New subjects and all subjects who replaced subjects who died during the study and follow-up period were sacrificed at the end of the 12th week. Group 1 was determined as the control group. Free fat grafts were placed into the laminectomy areas in group 2. In group 3, ADCON-L was injected into the surgical area. Subjects were sacrificed at week 12. After decalcification, laminectomy zones were taken into routine tissue follow-up for histopathological examination. Results: When group-1 and group-3 were compared regarding fibroblastic proliferation, there was a statistically significant difference (p<0.001). When group-2 and group-3 were compared, it was determined that fibroblastic proliferation was statistically higher in group-2 (p<0.001). When group-1 and group-3 were compared in terms of collagen amount, the amount of collagen in group-3 was significantly less (p<0.001). When the groups were evaluated statistically regarding the adhesion of the scar tissue to the dura, there was a significant difference between group-1 and group-2 (p<0.01). Adhesion was significantly less in group-3 compared to group-2 (p<0.001). Conclusion: We concluded that ADCON-L did not cause FBS syndrome. So, ADCON-L is more successful than free fat graft in the prevention of epidural fibrosis after laminectomy in spinal surgery.