Abstract
1. The present study was undertaken to investigate effects of Ba 2+ on the isolated frog lung strips depolarized by 20 mM K + in Ca 2+ free Ringer solution. 2. Ba 2+ produced monophasic relaxant response, whereas Ca 2+ induced biphasic response consisting of a transient relaxation and a marked contraction. Both kinds of relaxation were inhibited completely by L-NOARG. L-arginine reversed the action of L-NOARG. 3. Ferrous sulfate, pyrogallol, hydroquinone, and vanadate reduced the Ba 2+-induced relaxation in a concentration-dependent manner. 4. These findings suggest that Ba +- induced relaxation may fully be mediated by the nitrergic mechanism and the effect of Ba 2+ on the nitric oxide synthase may be more selective than Ca 2+.
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