Abstract
Torsade de pointes (TdP) is associated with long QT (LQT) syndromes which can be precipitated by altering cardiac potassium currents e.g. IKr (LQT2) or the cardiac sodium current INa (LQT3). The aim of this study was to test the hypothesis that ATX-II will potentiate E-4031-induced TdP. Experiments were performed in pentobarbital-anaesthetized α1-adrenoceptor-stimulated male New Zealand White rabbits. Rabbits were given increasing doses of either the INa opener ATX-II (n=6), the IKr blocker E-4031 (n=6), or both drugs in combination (n=6).
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