The effect of atropine on bile secretion in dogs.

Abstract

Five mongrel dogs weighing 16 to ‘24 kilograms were prepared by cholecystectomy, ligation of the lesser pancreatic duct, insertion of a modified Thomas cannulall into the duodenum opposite the opening of the common bile duct, and insertion of another Thomas cannula into the stomach. Starting no sooner than three weeks postoperatively, experiments were performed no more often than three times weekly. Following a 16 hour fast, the gastric and duodenal cannulas were unstoppered and a polyethylene tube (Intramedic PE-190, O.D. 1.7 mm.) was inserted 4 to 6 cm. into the common bile duct and brought out through a hole in the cork used to occlude the duodenal cannula. Biliary and gastric secretions were collected in 15 minute samples throughout each experiment. Each dog received a continuous intravenous infusion at 66 ml. per hour from a calibrated peristaltic pump (Harvard Ap-