Abstract
Aim: of the study is to evaluate the effectiveness of Аctive Hexose Correlated Compound (АНСС®) use in monotherapy and its impact on the echographic characteristics of the thyroid gland during (multi) nodular goiter. Methods: The study involved 27 people with (multi) nodular euthyroid goiter. The main treatment group consisted of 13 patients who received АНСС®. The placebo control group consisted of 14 participants. The duration of the drug intake lasted for 100 days. Three visiting schedules were arranged including initial, intermediate and final visits. Research methods included clinical examinations, laboratory tests, a thyroid ultrasound (classification by K-TIRADS) and completing a questionnaire. Results: The laboratory tests confirmed the euthyroid status of patients in both groups at baseline and at the end of the study. A decrease in the total volume of the right and left lobes of the thyroid gland was noted among the main treatment group. In addition, a decrease in the volume of all types of nodules was seen in this group. A decrease in the volume of the type 2 colloid node was statistically significant. On the contrary, a statistically significant increase in the average volume of the same type of node among the control group was seen. Overall, the average volume of the node decreased by 37.2% in the main group and increased by 4.9% in the control group by the end of the study. Conclusion: The results of this double-blind, placebo-controlled study make it possible to assess the efficiency of АНСС® in (multi) nodular goiter affecting primarily the volume of nodes (mainly of the 2nd and 3rd types). This is especially important when a potential surgery or radioiodine therapy may carry a high risk of complications among patients.
Highlights
The importance of this study is related to high prevalence of the most common condition of the thyroid gland - nodular euthyroid goiter (MEG), especially in iodine-deficient regions [1,2,3]
The aim of this study is to evaluate the effectiveness of АНСС® in monotherapy and to assess its effect on the echographic characteristics of the thyroid gland during nodular goiter
We revealed a statistically significant decrease in the average volume of nodes in the main treatment group from 3.45 (2.7; 5.2) cm3 to 2.17 (0.3; 4.5) cm3 by the end of the observation, as an evidence of АНСС®’s positive effect
Summary
The importance of this study is related to high prevalence of the most common condition of the thyroid gland - (multi) nodular euthyroid goiter (MEG), especially in iodine-deficient regions [1,2,3]. There are no exact statistics on the prevalence of this condition and some studies suggest a 20-65% increase of its frequency with older age. This figure exceeds up to 50% according to ultrasound and autopsy data. Despite the Journal of Clinical Medicine of Kazakhstan: 2021 Volume 18, Issue 2 seeming harmlessness, the thyroid nodes increase in size, causing compression of the surrounding organs, and may lead to the formation of functional autonomy. More often than in other territories, nodular goiter (NG) can degenerate into malignant formations [1,3]
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