Abstract
Atenolol is one of beta-adrenergic receptor blocking agent. It is widely used for the treatment of hypertension as a selective antihypertensive drug. But long term usage of atenolol may cause one of the cardiovascular diseases like myocardial infarction. To prove the relationship between atenolol and cardiovascular disease, measurement of creatinekinase-MB as a diagnostic indicator in early and long term usage of this drug by hypertensive patients is recommended. A comparative study was conducted in Al-Yarmouk Teaching Hospital–Emergency Department- on 30 hypertensive patients using atenolol. They were divided into (2) groups A and B according to the duration of the drug usage. Group A- (15) patients with a mean age (56+6) years. They used atenolol for a period of (1-5) years. Group B- also (15) patients with mean age (60+6) years. They used atenolol for (6-20) years. Both groups were with nearly the same number of males and females. All subjects of the study groups were screened to exclude evidence of hyper or hypothyroidism, diabetes and chronic renal failure. Venous blood samples were taken in first 8 hours after onset symptoms of cardiac attack from each patients and the levels of creatine kinase-MB were estimated and compared between the (2) groups. There is a significant correlation between levels of serum creatine kinase-MB of group A and group B (P<0.05). Atenolol causes increased level of serum CK-MB and this increase was directly proportional to the duration of the drug usage. CK-MB is one of cardiac markers that released from heart muscle when it is damaged as a result of myocardial infraction. So, atenolol has a significant correlation with development of myocardial diseases.
 Key words: hypertension , Atenolol and side effects , creatine kinase-MB , Atenolol antihypertensive.
Highlights
Atenolol is one of beta blockers acts by blocking beta receptors that are found in diseases as angina pectoris, hypertension, arrhythmias and in prevention of heart attack(4).various parts of the body, and prevents the action of nor-adrenaline and adrenaline(1).The prolong use of this drug as antihypertensive may show different sideAtenolol is rapidly absorbed from the gut.effect which may develop to symptoms ofBlood level reached a peak concentration in (23) hours(2)
The correlation between atenolol duration 1-5 years and CK-MB (u/L) in patients included in the study ( y = 2.4336x+2.5759, R2 = 0.236, r=0.486, P=0.066 (Not significant))
The correlation between atenolol duration 6-20 years and CK-MB (u/L) in patients included in the study (y= -0.3751x+24.188, R2= 0.277, r= -0.166, P= 0.553 (Not significant))
Summary
Atenolol is one of beta blockers acts by blocking beta receptors that are found in diseases as angina pectoris, hypertension, arrhythmias and in prevention of heart attack(4).various parts of the body, and prevents the action of nor-adrenaline and adrenaline(1).The prolong use of this drug as antihypertensive may show different sideAtenolol is rapidly absorbed from the gut.effect which may develop to symptoms ofBlood level reached a peak concentration in (23) hours(2). Atenolol is one of beta blockers acts by blocking beta receptors that are found in diseases as angina pectoris, hypertension, arrhythmias and in prevention of heart attack(4). Various parts of the body, and prevents the action of nor-adrenaline and adrenaline(1). The prolong use of this drug as antihypertensive may show different side. Atenolol is rapidly absorbed from the gut. Effect which may develop to symptoms of. Blood level reached a peak concentration in (23) hours(2). Metabolism of atenolol is minimal cardiovascular disease. Creatine Kinase-MB is one of the isoenzymes of creatine kinase which and almost the total absorbed drug (85-100)%. Atenolol is the creatine kinase-MB as an important biological marker, when it appears in abnormal drug of choice in different cardiovascular level>10u/L in serum
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