Abstract
Background: Inflammatory respiratory tract involves the interaction of several mediators that will cause asthma symptoms. This study aimed to reveal the effect of asthma exercise on cortisol hormone and interleukin-5 (IL-5) in the Indonesian patients with persistent asthma. Methods: This is a pre and posttest-designed experimental study in the Prof. Dr. Margono Soekarjo Hospital at Purwokerto, Indonesia. The diagnosis of asthma was established according to the Global Initiative For Asthma 2017. IL-5 levels were determined from peripheral blood mononuclear cells, and cortisol hormone analysis was performed by enzyme-linked immunosorbent assay technique. All parameters were tested before and after performing asthma exercise 4 times/week in 8 weeks with a duration of 60 min. The Wilcoxon and Pearson tests were performed for the statistical analysis. Results: Asthma exercise significantly increased the cortisol hormone levels (P
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