The Effect of Aspirin on HbA1c Assay Among Diabetic Hypertensive Patients Attending Abu Aqulah Centre in Wad Madani, Gezira State, Sudan

Abstract

<i>Background and Objective:</i> Diabetes is one of the most common diseases in the world, and its prevalence has increased dramatically in the last century until it reached approximately 422 million in the world. The increase in disease has lead to a decrease in production and an increase in financial costs for patients, several methods were taken to diagnose diabetes millets such as glucose tolerance and fasting glucose measurement until the Ministry of World Health approved in 2011 that hemoglobin A1c is suitable for diagnosing and controlling diabetes. But some studies indicated Hemoglobin A1c is affected by aspirin and other factors that can give false results and affect diagnosis or monitoring. So this Cross-Sectional study was conducted and the aim to study the effect of aspirin on hemoglobin A1c among diabetic hypertensive, to determine the effect of aspirin, age, sex and fasting glucose on HbA1c concentration. <i>Materials and Methods:</i> ichroma was used for measuring HbA1c and colorimeter for measuring fasting blood glucose. Questionnaire for age and sex, the venous sample were collected in (EDTA) Ethlyine Di amin tetra acetic acid for HbA1c measuring and fluoride oxalate for fasting measuring. The study was done at Wad Madni and included 100 patients with diabetes and hypertension, 50 of them used aspirin, while the other 50 did not use aspirin. <i>Results:</i> The result of the study was increased in HbA1c in patient use aspirin more than 2 years HbA1c mean was (9.7) and less in patient use aspirin less than 2 years HbA1c mean (9.4), p value (0.048). The comparison between male and female the HbA1c was more in female (10.6) than male (9.2), p value (0.045) also HbA1c associated with BMI and fasting glucose. The statistically package for social studies (SPSS) version 20 programs was used for the analysis of data. Relative risk and odd ratio also should be calculated was used for statistical analysis. <i>Conclusion:</i> The level of HbA1c is increase with aspirin using and associated with fasting blood glucose and BMI. And female have high level of HbA1c than male. The age of patient not effect on HbA1c level.