Abstract
1. Asphyxia at first increases the responses to potassium and acetyl-choline, then depresses them. 2. The decline of excitability is affected by the nature of tone. 3. The resistance to asphyxia of various responses varies in the following order: Nervous stimulation < electrical stimulation < acetylcholine < potassium. 4. Tone-producing substances depress the response of asphyxiated frog’s unstriated muscle, if the latter is stimulated about once in 10–15 minutes. In mammalian muscle the result is opposite. 5. Glucose has at first an inhibitory and then a stimulatory action on the response of unstriated muscle to potassium; if the metabolism is increased by raising the temperature, then, the effect becomes stimulatory the outset. 6. Iodoacetic acid increases the response to potassium after a preliminary depressant effect. 7. pH 6 increases the response to acetylcholine and potassium after a preliminary depressant effect.
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