The effect of aseptic proliferative inflammation on the localization and growth of spontaneous tumors of the mammary glands in mice of the high-cancer C3HA strain

Abstract

Experiments were performed on 160 female mice of the highly cancerous strain C3HA with the so-called “milk factor”. These experiments were aimed at studying the effect of proliferative inflammation on the growth of cancer. This proliferative inflammatory process was induced by the injection of 0.3 ml of 10% emulsion of infusorial earth in peach oil. At the age of 5 months the same mice received a repeated injection of 0.3 ml of 10% emulsion of infusorial earth in peach oil into the same site. Experiments demonstrated that the inflammatory process considerably affected the localization and the time of appearance of the tumors of the mammary glands. The neoplasms most frequently occur in the mammary gland affected by the proliferative inflammatory process. These neoplasms appeared in younger mice in comparison with the analogous group of control animals. The author assumes that the foci of the cellular proliferation caused by the inflammatory process create favorable conditions for manifestation of pathogenicity of the virus causing spontaneous cancer of the mammary gland.