THE EFFECT OF AROMATASES INHIBITOR-BASED PRODUCTS ON COW REPRODUCTIVE ABILITY

Abstract

Mycotoxin zearalenone is a phytoestrogenic substance that can disrupt the functioning of the organs of the reproductive system of cows. At the same time, a hyperestrogenic state occurs, which
 leads to overeating, multiple unsuccessful inseminations and infertility of cows.
 The purpose of the research is to investigate the effect of a single application of drugs based on aromatase inhibitors on the main biochemical and hormonal parameters of the blood of cows, as well as to establish their effectiveness during spontaneous expression of desire and when applying synchronization schemes.
 The effect of a single dose of aromatase inhibitors on the dynamics of sex hormones in cows, which directly affect the formation of the dominant follicle and its ovulation, was investigated. At the same time, a 1.56-fold decrease in estradiol, a 1.67-fold increase in progesterone, a 1.29-fold increase in luteinizing hormone, and a 1.76-fold increase in follicle-stimulating hormone were found. At the same time, the maturation of the dominant follicle and its ovulation at a size of 22 to 24 mm have been established. A change in the biochemical parameters of the blood serum of cows after the use of products based on an aromatase inhibitor was revealed. A tendency was established to restore the level of calcium to 2.01±0.27 mmol/l, phosphorus – 1.1±0.41 mmol/l, magnesium – 0.87±0.11 mmol/l, selenium –1.0± 0.1 mmol/l. At the same time, the level of creatinine decreased by 1.2 times compared to sick animals, the indicators of liver transferases also tended to decrease. A significant decrease in the blood urea index by 1.69 times was established, which indicates the restoration of protein and lipid metabolism.
 The indicators of fertilization of cows with spontaneous manifestation of sexual desire when using agents based on aromatase inhibitors were studied. At the same time, the fertility rate ranged from 69.39% in cows older than 5 years to 80.39% in cows after the 1st calving.
 A positive effect of aromatase inhibitors, introduced before the use of estrus synchronization schemes in cows, was established on the development of the dominant follicle, luteogenesis and the appearance of a new wave of follicle development. Fertilization averaged from 68.1% to 76.42%.