Abstract
Purpose: To evaluate the effect of topical aqueous humor suppressants on the absorption of intravitreal perfluorocarbon gases. Methods: Sulfur hexafluoride or perfluoropropane was injected intravitreally in five rabbits. Time to gas disappearance was measured in eyes treated with topical aqueous humor suppressants and in those not treated. Results: The mean time (± SD) to disappearance of 0.4 cc of sulfur hexafluoride was 5.6 ± 0.9 days, which was prolonged by 43% to 8.0 ± 0.7 days with topical aqueous humor suppressants ( P = .009). The mean time (± SD) to disappearance of 0.2 cc of perfluoropropane was 18.4 ± 1.9 days, which was prolonged by 55% to 28.6 ± 2.7 days with topical aqueous humor suppressants ( P = .009). Conclusion: Aqueous suppressants prolong sulfur hexafluoride and perfluoropropane intravitreal gas bubble duration in rabbits.
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