Abstract
Nigella sativa (NS) or also known as black seeds is one of the traditional herbs that were identified to have anticancer properties due to the presence of an active compound, thymoquinone. In this study, the cytotoxic effect of the aqueous extracts of NS were tested on the breast cancer cell line, MCF-7. Aqueous extraction of NS using cold water producing 3.8% of yield. The cytotoxic effect of aqueous extracts of NS were tested after incubation at 5 hours, 24 hours and 48 hours by using a modified MTT colorimetric assay. Interestingly, the IC50 of aqueous extracts of NS on MCF-7 was at 11.5 µg/ml. Additionally, aqueous extracts of NS at the concentration beyond 11.5 µg/ml causing the swelling of MCF-7 and leads to cell burst. In conclusion, aqueous extracts of NS have been proved to have cytotoxic effect on MCF-7.
Highlights
INTRODUCTIONMedicinal plants were widely used during the ancient time
According to a study, medicinal plants were widely used during the ancient time
Ethnopharmacology have been playing major roles to contribute in the development of alternative medicines and they worked hard to produce on medicinal plant research [6,7]
Summary
Medicinal plants were widely used during the ancient time This was recorded in many ancient books such as Unani, Ayurveda, Chinese and Arabic Medicines [1,2,3,4]. Those plants gain serious attention in modern science and western medicines because of the presence of phytochemical potential and being new discovered drugs with high selectivity on drug design, which that link the traditional and modern medicine [5]. Nigella sativa (NS) or commonly known as habbatus-sauda is one of the wellknown medicinal plants that has a lot of benefits to maintain health and cure various diseases. This study investigates the potential cancer inhibition of aqueous extracts of Nigella sativa on breast cancer MCF-7 cell lines
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