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Abstract
Problem statement: Rheumatoid Arthritis (RA) is one of the common autoimmune diseases with unknown etiology that its prevalence ratio in females to males is 3:1. It has been suggested that serum antioxidant levels is reduced and lipid peroxidation is increased due to oxidative stress. According to a recent research, antioxidant supplements may play an important role in controlling oxidative stress. The aim of this study is to investigate the effect of antioxidants supplement on serum Aryl Esterase Enzyme (ARE) and serum Malondialdehyde (MDA) in RA patients. Approach: A pre-post study was conducted in a 3 month period on 40 female RA patients which receiving daily one SelenPlus capsule (selenium 50 mcg, zinc 8 mg, vitamin A 400 mcg, vitamin C 125 mg and vitamin E 40 mg). About 5 mL venous blood sample was taken from all participants and serum levels of ARE and MDA were measured spectrophotometerically. Distribution of the variables were assessed using histogram with normal curve as well as Kolmogrov-Smirnov test and Data were analyzed with paired t test for differences between pre-post data using SPSS software version 13.5. Results: Out of 40 patients, 39 completed the study. In comparison with the baseline, we found significant differences between serum aryl esterase and malondialdehyde values before and after intervention. The 3-month supplementation resulted in increasing ARE activity (p<0.001) and reduction of MDA levels (p<0.001). Conclusion: The antioxidantssupplement for 3 months resulted in significant improvement in ARE activity and reduction of lipid peroxidation marker and may be helpful in RA treatment.
Highlights
The RA has direct connection with other chronic diseases like cardiovascular diseases that are the mostRheumatoid Arthritis (RA) is one of the most important problems of public health in community common autoimmune diseases with unknown etiology (Goldberg and Katz, 2007; Yang et al, 2010)
J. 2 (2): 119-124, 2011 medications with nutrients, disability in movement examination was performed by Rheumatologist and and long-term gastrointestinal complications; filled up the forms of personal data, medications, food malnutrition is common in RA patients, so dietary intake for 3 days (2 working days and a regular holiday) antioxidants intake has been reduced
The similar results were obtained by Shinde et al (2010) that indicated the effect of antioxidant vitamin supplements on significant reduction in serum levels of malondialdehyde (p
Summary
The RA has direct connection with other chronic diseases like cardiovascular diseases that are the mostRheumatoid Arthritis (RA) is one of the most important problems of public health in community common autoimmune diseases with unknown etiology (Goldberg and Katz, 2007; Yang et al, 2010). In Iran, the of dietary antioxidants with the incidence of RA incidence of RA in one million people is approximately (Karatas et al, 2003; Pattison and Winyard, 2008). The With the reduction of dietary intake of antioxidants, the main characteristics of Rheumatoid arthritis are amount of antioxidant enzymes including serum aryl swelling, pain and physical movement impairment that esterase are reduced J. 2 (2): 119-124, 2011 medications with nutrients, disability in movement examination was performed by Rheumatologist and and long-term gastrointestinal complications; filled up the forms of personal data, medications, food malnutrition is common in RA patients, so dietary intake for 3 days (2 working days and a regular holiday) antioxidants intake has been reduced
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