Abstract
Two compounds which are both antimetabolites and precursors of vitamin B12, o-phenylendiamine, and 5,6-dimethylbenzimidazole, stimulated the production of vitamin B12 by Propionibacterium freudenreichii at concentrations which were subinhibitory for growth. The stimulatory effect of the compounds depended not only on their concentration, but also on the time of addition. During cultivation, two chromatographically distinguishable fractions with vitamin B12 activity were formed. At concentrations which stimulated production of vitamin B12, only the biosynthesis of true vitamin B12 (cyanocobalamin) took place, while the biosynthesis of the analogue with a higher molecular weight was inhibited.
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