The Effect of Antibiotic Growth Promoters (AGP) on Antibiotic Resistance and the Digestive System of Broiler Chicken in Sleman, Yogyakarta

E.M Nugraha Setyawan,E Choiriyah,V Budiariati,R Widayanti,Widya Asmara,Tri Untari,A Haryanto,Okti Herawati,Michael Haryadi Wibowo,M Arif,A.D Wijayanti,M Anggita,Marla Anggita,W.S Nugroho,Agnesia Endang Tri Hastuti Wahyuni,D.A Widiasih

doi:10.1051/bioconf/20213304005

Abstract

Chicken is a major source of animal protein consumption in Indonesia. The problem facing the poultry industry is the incidence of resistance which increases mortality of the chicken production. One of the causes of resistance case is the use of antibiotics in feed additives. The public understanding about the effects of the use of antibiotic growth promoters (AGP) in chickens in antibiotic resistance and the digestive tract of chicken needs to be done to avoid the impact on economic losses and health problems. This study aims to provide an understanding of the effects of the use of antibiotic growth promoters (AGP) on antibiotic resistance and the digestive tract of broiler chickens. This study was carried out at a broiler chicken farm in Sleman, Yogyakarta. Based on the histopathological result of the digestive tract of chickens that were given antibiotics as AGP, there was no inflammation occurs, but the administration of antibiotics caused antibiotic resistance in various type of antibiotics including tetracycline (90% resistance), streptomycin (60% resistance), amoxicillin (50% resistance), erythromycin (80% resistance), and no resistance for gentamycin.

Highlights

Poultry is acknowledged as the main animal protein source in Indonesia, based on the report from [1]
This study aims to provide an understanding of the effects of using antibiotic growth promoters (AGP) on antibiotic resistance and digestive tract of broilers
Five antibiotic disks: gentamicin 10 μg, tetracycline 30μg, streptomycin 10μg, amoxicillin 25 μg and erythromycin 15μg, were placed on the surface of Mueller Hinton agar (MHA) incubated for 18-24 hours

Summary

Introduction

Poultry is acknowledged as the main animal protein source in Indonesia, based on the report from [1]. The control and surveillance of antibiotics used in poultry farm is still lacking. A large number of antibiotics used in poultry industry are used for human medicine, and so considered to be of high importance. Resistance can be transferred to other animals or humans through direct contact, food-produced animal products, or indirectly via environmental pathways [3]. After the first introduction of antibiotic growth promoters, the products have been used in farm animals massively. The mechanism of antibiotics as growth promoters are still unknown. Antibiotics are given through food during the growing period of broiler chickens to prevent diseases [6]

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