Abstract
Repeated carotid artery injections of contrast media were performed in cats and cerebral biopsy samples obtained for electron microscopy. Evidence suggests that there are two methods by which the blood-brain barrier may break down with repeated angiography: (a) alteration of the tight junctions between capillary endothelial cells in the brain, allowing passage of matter through these junctions, and (b) transport across the endothelial cells by pinocytosis.
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