Abstract
High intraocular pressure (IOP) is a recognized risk factor for glaucoma and optic nerve injury, and it is one of the primary causes of vision loss globally. Anabasis articulata (AA) is a desert plant found in Iraq. The extract of AA is used to cure diabetes, fever, eczema, and kidney infections. The aim of the study is to evaluate the antioxidant effect of methanol extract of AA on intraocular pressure in the glaucoma rat model. Forty-two rats were allocated into seven groups, each with six animals:: group 1 (normal), group 2 (control), in which animals were induced to have elevated IOP by betamethasone suspension injection, groups 3,4 and 5 for evaluating the effect of 50,100 and 150 mg/kg/day of the tested extract, respectively, and the remaining two groups (group 6 and 7) for evaluating oral acetazolamide and topical timolol 0.5% respectively. Betamethasone was used for the induction. Measure the IOP every 2 days for 2 weeks. The daily dose of AA extract (50 mg/kg/day) for 6 days significantly reduces intraocular pressure (p ? 0.05), from (34.23± 0.58) to (32.83± 1.38) mmHg when compared with the control group. In group 4, IOP decreased significantly from (35.5±1.37) to (31.35±0.40) mmHg (p ? 0.05) after 1 week of treatment. In group 5, the significant (p? 0.001) IOP reduction from (35.66±0.39) to (31.88±0.74) mmHg started on day 6 and continued until the end of the experiment, reaching (24.53±0.53) mmHg (p? 0.001). The antioxidant and anti-angiogenic properties of AA make it a promising adjuvant treatment for glaucoma.
Highlights
High intraocular pressure (IOP) is a recognized risk factor for glaucoma and optic nerve injury, [1], and it is one of the most common causes of blindness in the world [2]
The right eye was used to induce chronic glaucoma models by weekly SQ betamethasone for 4 weeks[15], and the left eye was used to evaluate whether oral test extracts had any adverse effects on the eyes
High IOP is still the most well-recognized risk factor for glaucomatous optic nerve injury, even though other variables may play a role in glaucoma
Summary
High intraocular pressure (IOP) is a recognized risk factor for glaucoma and optic nerve injury, [1], and it is one of the most common causes of blindness in the world [2]. Glaucoma affected approximately 64.3 million people worldwide in 2013, putting them at risk of blindness. This number is expected to rise to 76.0 million in 2020 and 111.8 million in 2040 [3]. The buildup of aqueous humor (AH) in the anterior chamber, which is mostly caused by the eye's failure to discharge aqueous fluid effectively, results in a high IOP[4]. Blood flowing through the ciliary body's arteries is the main cause of aqueous humor. The ciliary body between the iris and lens secretes aqueous humor , the fluid of this region
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Schedule a callMore From: Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512)
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