Abstract
Pure oxfendazole (OFZ) suspended in peanut oil and the commercial formulation ‘Synanthic’ were each intraruminally administered to Merino weaners at 5 mg kg −1. Plasma was collected and concentrations of OFZ, fenbendazole (FBZ) and FBZ sulphone (FBZ.SO 2) were determined by HPLC. The maximum concentrations and area under the plasma concentration curve (AUC) of OFZ and FBZ were significantly higher ( P < 0.05) when OFZ was suspended in peanut oil than when administered as the commercial formulation.
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