The Effect of An Aqueous Extract of Vitex Agnus-Castus Leaves on the Liver and Kidney in Female Rabbits

Abstract

According to their accessibility and lower cost-effectiveness when compared to synthetic chemical treatments, medicinal wild plants and herbs have been used for ages as beneficial tools in the management of many diseases. The popular medicinal plant Vitex agnus-castus, which is indigenous to the Mediterranean region and widely distributed in Europe, Asia, and North Africa, is used to treat a number of conditions and diseases, including premenstrual syndrome, mastalgia, infertility, and menstrual cycle management. The current study examined how the aqueous extract of the vitex plant compared to clomiphene citrate in female rabbits. In this experiment, nine female rabbits were divided into three equal groups. Aqueous vitex plant extract was administered to the first group for 15 days, clomiphene citrate was administered to the second group for 5 days as aspect of an approved course of treatment, and distilled water was administered to the third group for 15 days as a control. To determine the impact of the aqueous extract of Vitex agnus castus on the functions of the female rabbits' body organs, the complete blood count (CBC) and GLU, UREA and CREA were calculated. In addition, the analyses of blood picture showed a significant disparity, enzymes; even histopathology results in compare with control which showed a significant decreasing in WBC count has observed in the vitex extract (F) group that was 4.7 for WBC and 4.45 for RBC while 9.8 for HGB. On the other hands, decreasing of WBC count observed significantly in the clomiphene citrate (C) group that was 3.9 for WBC and 5.3 for RBC while HGB was 6.4mg.