Abstract
The purpose of the study is to examine the effect of anesthesia and respiratory support parameters on central and peripheral hemodynamics in patients with morbid obesity undergoing an endoscopic gastric resection. Materials and methods. A randomized study of 43 patients with a body weight index of >40 kg/m2 who underwent an endoscopic longitudinal gastric resection (sleeve gastrectomy) was performed. Patients were divided into two groups. In Group 1 (n=22), combined anesthesia based on the low%flow desflurane inhalation was applied along with the mechanical ventilation in the VC%CMV mode with a constant PEEP level. In Group 2 (n=21), combined anesthesia based on the low-flow desflurane inhalation was applied along with the prolonged epidural analgesia (PEA) with 0.2% ropivacaine solution and VC%CMV respiratory pattern, with PEEP dose escalation using titration, inverted respiratory cycle, and a gradual increase in the respiratory rate. The intraoperative monitoring included central and peripheral hemodynamics, blood gases, and ABB.Results. The study demonstrated that there was more stable central and peripheral hemodynamics in Group 2 during the intraoperative period as compared to Group 1, where increased systolic BP, median NMBP, diastolic BP, HR, CI, SVI, and SVRI levels were registered. In addition, in Group 2, РаO2 levels were significantly higher and РCO2 levels were lower during pneumoperitoneum; no significant changes in ABB were recorded. Conclusion. Thoracic epidural analgesia with pneumoperitoneum, increased intraabdominal pressure, and PEEP escalation mode provide stable intraoperative central and peripheral hemodynamics during endoscopic gastric resection in patients with morbid obesity.
Highlights
Распространенность больных ожирением уве личивается во всем мире
In group 1 (n=22), a combined anesthesia based on the low flow desflurane inhalation using a routine mode of mechanical ventilation (MV) was applied as an anesthetic management: VC CMV mode, Vt 7—8 mL / kg of ideal
A study of central hemodynamics demonstrated a decrease in Cardiac index (CI) and stroke volume index (SVI) to the lower normal limits; and no significant differences between groups were registered (Table 1); there was a significantly lower central venous pressure (CVP) in both groups as compared to the nor mal limits (P
Summary
Распространенность больных ожирением уве личивается во всем мире. Число больных ожирением превыси ло 600 млн. При выборе анестезиологического обеспечения этих травматичных вмешательств необходимо учи тывать анатомические и функциональные измене ния у пациентов с морбидным ожирением, в первую очередь — сердечно сосудистой системы. При выполнении этих операций в определенной сте пени необходима реализация принципа fast track, поскольку ранняя активизация этих больных — за лог благоприятного течения раннего послеопераци онного периода [5, 6]. В этих условиях интраопера ционный мониторинг системы кровообращения является неотъемлемым компонентом анестезиоло гического обеспечения абдоминальных эндоскопи ческих операций. Цель исследования — изучить влияние метода анестезии и параметров респира торной поддержки на центральную и периферичес кую гемодинамику у пациентов с морбидным ожи рением при эндоскопической резекции желудка
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