The effect of amphotericin lotion on cutaneous moniliasis.

Abstract

This is a preliminary clinical report of a new amphotericin B 3% lotion * for various cutaneous Candida albicans infections. Amphotericin B is a polyene antifungal antibiotic, useful for the treatment of many mycotic infections. It has been used extensively in the management of the deep-seated mycoses. In this study, 35 patients were placed on amphotericin lotion for periods varying from 1 to 6 weeks. These cases included 23 cases of monilial intertrigo involving the groin, perianal, perineal, inframammary, or axillary areas. In addition, 6 cases of monilial paronychia, 2 cases of erosio interdigitalis blastomycetica, 3 cases of generalized moniliasis in infants, and 2 cases of primary seborrheic eczema of long standing with secondary monilial involvement, proven by direct microscopic examination, were treated. In each case, direct and cultural confirmation of the diagnosis was obtained. Each patient in the study was given 30 cc. bottles of amphotericin lotion and was directed