Abstract
SUMMARY A mild acidosis was induced in goats and cows by oral administration of ammonium chloride. The effects of this treatment on the accretion rate of calcium into bone and on the size of the exchangeable calcium pool were investigated using the radioisotopes 85Sr and 45Ca. Ammonium chloride was found to cause a significant increase in exchangeable calcium and a reduction in accretion rate. In contrast oral administration of sodium carbonate or ammonium acetate was found to reduce the size of the exchangeable calcium pool. In some but not all animals mild acidosis increased the absorption of calcium from the alimentary tract. All these changes suggest that mild acidosis, as induced by ammonium chloride, might improve calcium metabolism in dairy cows. This might be particularly effective in animals receiving relatively alkaline diets and might be of benefit in the prevention of such diseases as parturient paresis.
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