Abstract
α-Amanitin inhibits the synthesis of polyoma specific RNA in cultured mouse kidney cells and in a coordinated way the synthesis of RNA stimulated by the presence of the virus. Late in infection, there is a preferential inhibition of polyoma mRNA synthesis. The results point to the involvement of host RNA polymerase II(B) in polyoma DNA transcription and suggest a possible modification of the enzyme late in infection.
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More From: Biochemical and Biophysical Research Communications
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