Abstract
Aloe vera aqueous extraction was examined for its immunomodulatory effect. Concentrated aqueous extraction was administrated orally 2ml/day for 30 days to the white mice, immunomodulatory effect was studied on total white blood cells (WBCs)count, phagocytosis, antibody titer and plaque forming cell (PFC). There is a significant increase in total count of WBC, reach 11300cell/ml3 at the day 28 after administration. Increase in phagocytosis activity was observed clearly after three and four week compared with control. Remarkable increase in the antibody titer against SRBCs for primary and secondary immune response (10.4±022, 14.2±2) respectively, and finally apparent effect on plaque forming cell (PFC) and maximum value was found after 5 days after immunization with SRBCs. It was 1200 PFC/106 of spleen cell.
Highlights
Aloe vera aqueous extraction was examined for its immunomodulatory effect
Our study investigated the immunological effect of aloe vera extract when adminstrated orally in white mice
The inner pulp was cut into small pieces, weighted to get 400gr, homogenized with 400ml of phosphate buffer saline (PBS) pH-5 by blender in cold condition and kept overnight in refrigerator, filtered through muslin clothes to get filtrate which centrifuged at 2000 rpm for 15min under cooled condition, discarded the green pellet and taken clear yellow supernatant concentrated by drying in sterile condition to 200ml and conserved in cold condition until used in experiment [6]
Summary
Aloe vera aqueous extraction was examined for its immunomodulatory effect. Concentrated aqueous extraction was administrated orally 2ml/day for 30 days to the white mice, immunomodulatory effect was studied on total white blood cells (WBCs)count, phagocytosis, antibody titer and plaque forming cell (PFC). Our study investigated the immunological effect of aloe vera extract when adminstrated orally in white mice. Animals were randomly divided into two groups, group A, control not received aloe vera extraction, 2ml of PBSwas added to the water. Group B, animal received 2ml of Aloe vera concentrated extraction added to the water.
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