The Effect of Allogenic Bone Marrow on Integration Dev-Mesenchymal Stem Cell And Vascular Endothelial Growth Factor

Abstract

Background: The integration of the tendon graft within the bone tunnel is one of the decisive success factors of the Anterior Cruciate Ligament (ACL) reconstruction. In ACL reconstruction that uses tendons as graft, the healing process that occurs in the bone tunnel is healing with fibrotic tissue. Aim: This study aims to determine the role of bone marrow mesenchymal stem cells and vascular endothelial growth factor intraarticularly in improving the biomechanical strength. Methods: This study uses experimental research design by using animal as a testing tool. The animals used in this study are male New Zealand white rabbits (Oryctolagus cuniculus), with the weight ranging of 2000 grams up to 3000 grams. Results: From the experiment, all samples from both treatment and control groups were all evaluated and no post-operative complication was found. At the evaluation time of 3 weeks, the difference between the mean of maximum strain rate between the treatment group and the control group was not statistically significant (p >0.05). At the evaluation time of 6 weeks, it was found that the difference in mean value of the maximum strain load force between the treatment groups versus the group was statistically significant. Conclusions: From this study, it can be concluded that intraarticular BM-MSC and VEGF administration can increase the ultimate tension strength of postoperative graft tendon rosary ACL reconstruction.