Abstract
Adolesterone has been shown to reduce 14CO2 release from [1-14C]glucose in the urinary bladder of the toad in vitro. This effect occurs at a time when 14CO2 released from [6-14C]glucose is enhanced, as is the metabolism of the tissue. However, in the absence of sodium, which abolishes the hormonal stimulation of metabolism, the effect of aldosterone to decrease 14CO2 from [1-14C]glucose is still demonstrable. The effects on glucose metabolism and on sodium transport appear to have the same time course of onset and dependence on the concentration of the hormone. Like the effect on sodium transport, it is abolished by actinomycin D at a concentration of 1.4·10−6 M. Dexamethasone and deoxycorticosterone (5·10−7 M) like aldosterone, stimulate sodium transport and decrease the 14CO2 from [1-14C]glucose whereas progesterone (5·10−7 M) fails to affect sodium transport and has no effect on glucose metabolism in this tissue. It is concluded, therefore, that this effect could stand in a cuasal relation to stimulation of sodium transport or that both could result from a common precursor affected by the hormone in the tissue. A third possibility is that this effect is an independent glucocorticoid effect of aldosterone. However, this would require that the similarities between the stimulation of sodium transport and the effect on glucose metabolism be coincidental.
Published Version
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