Abstract
Cardiac scintigraphic studies using [ 123I]MIBG have demonstrated a heterogeneous myocardial accumulation of radioactivity in diabetes. Recently, we have shown that this accumulation of MIBG was correlated with a heterogeneous decrease in the level of norepinephrine transporter (NET). In diabetes, an aldose reductase (AR) is activated in the peripheral nerve tissue, and the sorbitol that accumulates causes nerve dysfunction and degeneration. Therefore, to assess the influence of AR on the reduction in NET, we investigated changes in the myocardial expression of NET and distribution of [ 12 5I]MIBG in a streptozotocin (STZ)-induced animal model of diabetes, the STZ rats, treated with AR inhibitor (ARI). NET expression levels were investigated and were lower in the inferior wall than anterior wall in STZ rats. On the other hand, there was no significant difference between the anterior and inferior walls in control or ARI rats. Regarding the distribution of [ 125I]MIBG, in STZ rats, there was significantly less uptake in the inferior than anterior wall. Conversely, there was no significant difference between the anterior and inferior walls in ARI and control rats. In conclusion, ARI suppressed the regional reduction of NET expression in diabetic rats, and this suppression prevented the heterogeneous accumulation of MIBG.
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