Abstract
The effect of age beginning from infancy to advanced age on the variations in the concentrations of deoxyribonucleic acid, ribonucleic acid and total nucleotides in liver, brain and muscle of rats was studied. The concentrations of DNA, RNA, and nucleotides in rat embryonic tissues were also determined. In the brain and muscles of very young rats the DNA and RNA concentrations are remarkably high and drop sharply and extensively, right from there with increasing age. In the liver the DNA and RNA concentrations show an increase after birth and drop rapidly thereafter, and then follow the same pattern of changes as noted in the case of muscle or brain. In muscle and brain tissues of rat embryo the concentrations of DNA and RNA are much higher than are found in corresponding tissues of young rats while in liver tissue of rat embryo their concentrations are much less. In young adults (100–400 g) the DNA and RNA do not undergo very significant change and in old age the RNA concentration goes up and the DNA concentration goes down, slightly in both cases. If the DNA and RNA values are expressed per organ, their values (contents) in liver show a steady increase with age. The total nucleotide concentration in brain is considerably higher than that found in muscle and liver. In muscle its concentration is higher than that found in liver.
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