Abstract
DW-MRS is a promising tool for the noninvasive identification of the cellular response to cerebral ischemia. To date, the potential confounding effects of aging and the stage of ischemia are unknown. We, therefore, examined the cross-sectional effects of age and different stages of cerebral ischemia on the diffusion of brain metabolites. The ADCs of 3 major metabolites, including Cho, Cr, and NAA were measured by DW-MRS in healthy younger (n = 26, 24 ± 2.2 years of age) and older (n = 17, 63 ± 7.0 years of age) adults, as well as in patients with acute (n = 7, 57 ± 4.0 years of age) and subacute (n = 12, 62 ± 7.8 years of age) cerebral ischemia. Compared with younger adults, healthy older adults presented with significantly reduced ADC values of NAA (P = .000052), Cr (P = .000018), and Cho (P = .00075). Meanwhile, the ADC values of NAA (F(2,36) = 6.057, P = .006), Cr (F(2,36) = 5.634, P = .008), and Cho (F(2,36) = 8.167, P = .001) were significantly different among the acute cerebral ischemia group, subacute cerebral ischemia group, and healthy older controls. These metabolites decreased in the acute stage of cerebral ischemia but increased in the subacute stage, compared with age-matched controls. The effect of age should be considered when analyzing diffusion of cerebral metabolites with DW-MRS. Our observations also suggest that metabolite diffusion data may be used to reveal changes in the intracellular environment, depending on the pathologic status of ischemia.
Highlights
ObjectivesThe goal of this study was to determine the crosssectional effects of both age and duration from the onset of cerebral ischemia on the ADCs of cerebral metabolites, by using PRESS-based DW-MRS sequences on a 3T MR imaging scanner
AND PURPOSE: DW-MRS is a promising tool for the noninvasive identification of the cellular response to cerebral ischemia
Our observations suggest that metabolite diffusion data may be used to reveal changes in the intracellular environment, depending on the pathologic status of ischemia
Summary
The goal of this study was to determine the crosssectional effects of both age and duration from the onset of cerebral ischemia on the ADCs of cerebral metabolites, by using PRESS-based DW-MRS sequences on a 3T MR imaging scanner. We aimed to find out the following: 1) whether aging is closely associated with the ADCs of metabolites in healthy volunteers, and 2) whether the different stages of cerebral ischemia will affect the level of diffusion of metabolites. The aim of this study was to offer an alternative method to understanding the physiologic and pathologic changes in different stages of cerebral ischemia
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