Abstract
The aim of this study was to investigate the effect of aerobic training and consumption of L-carnitine supplements on HMG-CoA reductase and LDL receptor in the liver of male Wistar rats toxicated by Boldenone. 30 male Wistar rats aged 12 weeks (weight 195±7.94g) were randomly divided into five groups: control, sham, boldenone (5mg/kg), L-carnitine, aerobic training- L-carnitine.The endurance moderate intensity training program (55-50% of maximal oxygen consumption) performed for 6 weeks and 5 times a week. Injection once a week, on an appointed day, and in the quadriceps and hamstring was conducted in depth. After anesthesia, autopsy was performed and the testes Isolated. The HMG-CoA reductase and LDL receptor expression in the samples was measured by Real Time PCR and the quantification of gene expression levels using the formula 2-ΔΔct were analyzed by One-way ANOVA and post hoc Scheffe at the significant level P<0. 05. The results showed that aerobic training and supplementation with L-carnitine was significant effect on HMG CoA reductase and LDL-R in the liver of male Wistar rats toxicated by boldenone (P=0/000). The results showed that the expression of HMG-CoA reductase changes in the liver of male Wistar rats in Group training - L-carnitine significantly lower than the control group (P=0/000). Changes in the expression of LDL-R in groups training - L-carnitine and L-carnitine increased significantly compared to control group (P=0/000). According to the findings, it seems to supplementation with L-carnitine with regular aerobic training modulating the biosynthesis of cholesterol in liver tissue.
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More From: International Journal of Applied Exercise Physiology
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