The effect of aerobic exercise on atheromatous plaques area and inflammatory-ralated serum cytokines of apoE-deficient mice

Abstract

In this study, ApoE-deficient mice was used as atherosclerosis(AS) model to approach the effect and mechanism of aerobic exercise on formation of atherosclerotic lesions and serum inflammatory-related cytokines. 20 ApoE-deficient mice were randomly divided into sedentary control group (SCG) and exercise group (EG, swimming, 90 min/d, 6 d/w, 10 wks), the lesion area and serum lipid and serum inflammatory-related cytokines were tested after 10 weeks. Compared with SCG, the lesion area in the aorta and the serum lipid of EG were improved significantly P<;0.05). The serum levels of TNF-α and IL-6 of EG were significantly down-regulated (P<;0.01), and the adiponectin level of EG was up-related(P<;0.01). The results suggested that aerobic exercise significantly improved the condition of apoE-deficient mice and simultaneously improved the fat metabolism. Aerobic exercise significantly decreased the pro-inflammatory cytokine and increased the anti-inflammatory cytokine simultaneously in apoE-deficient mice.