Abstract
THE thyroid-adrenal interrelationship has interested medical investigators for over fifty years. A protective action of adrenocortical steroids against thyroid intoxication has been shown repeatedly (1–11). The experiments of Marine and Baumann (12, 13), which were confirmed by others (14–16), demonstrated an apparently increased activity of the thyroid in the presence of partial adrenal cortical insufficiency. The lymphoid and thymic hyperplasia in hyperthyroidism, as well as in adrenal cortical insufficiency (2, 17–20), the involution of these tissues by adrenal cortical steroids (21–23), and the inactivation of thyrotropic hormone by the same tissue (24) all point to a close physiologic relationship between the thyroid and adrenal glands. A depression of thyroid function in animals and in man has been reported following stress, the administration of cortisone acetate (11-dehydro-17-hydroxycorticosterone acetate), ACTH (adrenocorticotropic hormone) and epinephrine (25–29). In patients with Addison's dis...
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