Abstract
In a previous paper (Landau, Knowlton, Lugibihl and Munson, 1950) we reviewed and extended the evidence relating the urinary excretion of dehydroisoandrosterone to adrenal cortical function. In the course of these studies a critical evaluation was made of the modified Pettenkofer reaction (Munson, Jones, McCall and Gallagher, 1948) employed as the means of estimating dehydroisoandrosterone and related steroids in neutral urine extracts. Since dehydroisoandrosterone and its two known hydrolytic artifacts, Δ5 androstadienone-17 and Δ5 3 (β) chlorandrostenone-17, possessed essentially the same chromogenic capacities and, in addition, were the only Pettenkofer chromogens which had been identified in ketonic extracts, it was felt that this procedure provided truer estimates of the dehydroisoandrosterone excreted than other methods. The chromogenicity of certain non-ketonic alcoholic steroids permitted rough approximations of this group as well. With this procedure available, the enhanced excretion of urinary 1...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
