Abstract
Abstrak. Latar Belakang: Eksaserbasi pada penyakit paru obstruktif kronik merupakan kondisi akut yang ditandai dengan hambatan aliran udara yang persisten dari respon inflamasi kronik yang berlebihan pada saluran napas dan parenkim paru yang disebabkan oleh paparan gas atau partikel berbahaya. Peningkatan peradangan saluran napas selama eksaserbasi menyebabkan peningkatan kadar IL-8 dan risiko rawat inap. Likopen merupakan karotenoid yang memiliki efek positif pada sistem pernapasan. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian likopen terhadap kadar IL-8 dan lama rawat inap pasien PPOK eksaserbasi akut.Metode: Uji eksperimental dengan desain pretest dan posttest pada 30 pasien PPOK eksaserbasi di RSUD Dr. Moewardi, Surakarta dan RSUD Dr. Soehadi Prijonegoro, Sragen dilakukan pada bulan Februari-Maret 2018. Pengambilan sampel secara consecutive sampling dibagi menjadi dua kelompok yaitu kelompok perlakuan yang mendapat terapi standar dan likopen 1x10 mg/hari selama pengobatan dan kelompok kontrol hanya mendapat terapi standar. Dilakukan pengukuran kadar IL-8 dan waktu rawat inap pasien dengan PPOK eksaserbasi.Hasil: Terdapat perbedaan yang bermakna antara kelompok perlakuan dibandingkan dengan kelompok kontrol untuk penurunan IL-8 (p = 0,029) dan penurunan waktu rawat inap (p = 0,000).Kesimpulan: Pemberian likopen 1x10 mg / hari secara signifikan menurunkan kadar IL-8 dan lama rawat inap pasien eksaserbasi PPOK.Kata kunci: eksaserbasi akut, kadar IL-8, lama rawat inap, likopen, PPOK.Abstract. Background: Exacerbated chronic obstructive pulmonary disease is an acute condition, characterized by persistent air flow limitations, related to the excessive chronic inflammatory response in the airways and lung parenchyma caused by exposure to harmful gases or particles. Increased airway inflammation during exacerbations leads to increased levels of IL-8 and the risk of hospitalization. Lycopene is a carotenoid which has a positive effect on the respiratory system. The purpose of this study was to determine the effect of administration lycopene to IL-8 levels and hospitalization time of patients with COPD disease exacerbations.Methods: The experimental test with pretest and posttest design for 30 patients with COPD exacerbations in Dr. Moewardi Surakarta Hospital and Dr. Soehadi Prijonegoro Sragen Hospital was conducted from February to March 2018. Samples were taken by consecutive sampling divided into two groups including the treatment group receiving standard therapy and lycopene 1x10 mg / day during treatment and the control group only receiving standard therapy. IL-8 levels and hospitalization time of patients with COPD disease exacerbations were measured.Results: There were significant differences between the treatment group compared to the control group for a decrease in IL-8 (p = 0.029) and a decrease in hospitalization time (p = 0,000).Conclusion: The administration of lycopene 1x10 mg / day significantly reduce IL-8 levels and hospitalization time of patient with COPD exacerbations.Keywords: lycopene, COPD, acute exacerbation, IL-8 level, hospitalization time
Highlights
Chronic obstructive pulmonary disease (COPD) is a disease that is a global health problem that causes an increase in morbidity and mortality, brings social and economic impacts, but can be prevented and treated which is characterized by limited persistent air flow, related to the chronic inflammatory response in the channel lung breath and parenchyma caused by exposure to harmful gases or particles.[1]
Leukotriene B4 (LTB4), interleukin 8 (IL-8), tumor necrosis factor-alpha (TNF-α), IL-1 beta (β), IL-6, and transforming growth factor β (TGF-β) are inflammatory mediators that play a role in the inflammatory process of COPD
The use of currently available anti-inflammatory is considered not yet effective enough because most cases of COPD are resistant to glucocorticoids due to damage to histone deacetylase 2 (HDAC2) caused by exposure to cigarette smoke and oxidative stress.[5]
Summary
Chronic obstructive pulmonary disease (COPD) is a disease that is a global health problem that causes an increase in morbidity and mortality, brings social and economic impacts, but can be prevented and treated which is characterized by limited persistent air flow, related to the chronic inflammatory response in the channel lung breath and parenchyma caused by exposure to harmful gases or particles.[1]. Air pollution, workplace exposure, and other harmful substances will cause an abnormal response of the airways and lungs, causing chronic inflammation involving multi-cells and inflammatory mediators. Exacerbated chronic obstructive pulmonary disease is an acute condition, characterized by persistent air flow limitations, related to the excessive chronic inflammatory response in the airways and lung parenchyma caused by exposure to harmful gases or particles. The purpose of this study was to determine the effect of administration lycopene to IL-8 levels and hospitalization time of patients with COPD disease exacerbations. IL-8 levels and hospitalization time of patients with COPD disease exacerbations were measured. Conclusion: The administration of lycopene 1x10 mg / day significantly reduce IL-8 levels and hospitalization time of patient with COPD exacerbations
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