The Effect of Administration of Kaempferia galanga L. Extract on Levels of Tumor Necrosis Factor Alpha (TNF-α) and Acute Pain Behavior in Post-Injury Wistar Rats

Abstract

Background: Untreated post-injury pain has negative effects in quality of life. Post-injury pain and inflammation have been treated with medication which have many side effects. The ethanol extract of Kaempferia galanga L. is believed have an important role in the control of mediators involved in inflammation. Methods: This is a randomized post-test only control group experimental design, using male Wistar rats. The samples were divided into 4 groups, control group (P1), treatment group given 150mg/kgBW ethanol extract (P2), treatment group given 300mg/kgBW ethanol extract (P3), and ethanol extract 600mg/kgBW (P4) The variables studied were TNF- α levels and acute pain behavior 4 hours after tissue injury Conclusion: Administration of Kaempferia galanga L. ethanol extract can reduce the inflammatory process by reducing TNF-α levels and reducing acute pain behavior after tissue injury compared to the control group. The highest dose of Kaempferia galanga L. extract in this study have a significant clinical response. Keywords: Kaempferia galanga L, post-injury, acute pain