Abstract
OBJECTIVE: The mesenchymal stem cell application to uterine healing scars may provide better tissue strength.STUDY DESIGN: Hysterectomy was performed on rats, and the wound recovery as a result of primary suturing was evaluated as tissue stretching and the positive histopathological effects. The mesenchymal stem cells originating from the adipose tissue were used during the healing period of the wound and would differentiate to mesenchyme-originated cells present in intact tissue for an optimum level of healing.RESULTS: The weights of non-incised uterine horns in the control group were found to be significantly higher than the weights of the incised uterine horns (z=2.52, p=0.012). In the experiment group, the weights of the incised uterine horns were found to be significantly higher than the non-incised uterine horns (z=2.527, p=0.012). In the control group, the non-incised uterine horns withstood the stretching test to a higher extent than the incised horns, and a significant difference was found between the stretching values (z=2.51, p=0.012). In the experiment group, the incised uterine horns withstood the stretching tests to a higher extent than the non-incised uterine horns; however, there was no significant difference between the stretching tests (z=1.540, p=0.123).CONCLUSION: Adipose tissue-originated mesenchyme stem cells were observed to increase the tissue stretching during wound healing.
Highlights
Stem cells are non-differentiated cells and yet have the ability to regenerate
Adipose tissue-originated mesenchyme stem cells were observed to increase the tissue stretching during wound healing
ATOSC was prepared from randomly chosen 3 rats that would be used in the experiment
Summary
Stem cells are non-differentiated cells and yet have the ability to regenerate. While they can differentiate into tissues theySubmitted for Publication: 20.12.2016 Accepted for Publication: 04.01.2017: The manuscript has been presented as an oral communication at the XXIV. Stem cells are non-differentiated cells and yet have the ability to regenerate. While they can differentiate into tissues they. Submitted for Publication: 20.12.2016 Accepted for Publication: 04.01.2017. : The manuscript has been presented as an oral communication at the XXIV. European Congress of Perinatal Medicine, Jun 6th, 2014, Florence, Italy. Quick Response Code: Access this article online Website: www.gorm.com.tr. How to cite this article: Bender RA. The Effect of Adipose Tissue-Derived Mesenchymal Stem Cells on Regeneration of Uterine Scars. Gynecol Obstet Reprod Med 2017;23(3):120128 originate from, they can differentiate into other tissues by means of the environment and biological stimulants [1]
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