Abstract
Background: Adiponectin is an adipose tissue-specific secretory protein and an important anti-inflammatory and anti-atherosclerotic factor. We evaluated the role of adiponectin on acute and chronic rejection using adiponectin transgenic mice. Chronic rejection of cardiac allograft is characterized by circumferential and diffuse intimal thickening of graft coronary artery developed several weeks after transplantation. Methods and Results: In an acute rejection model, BALB/c murine hearts were transplanted into adiponectin sense transgenic (Tg-S) mice (full allomismatch).
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