Abstract
Adenosine counteracts caffeine-induced cytokenesis inhibition in meristem cells of onion root tips; counteracts caffeine-induced cytokinesis inhibition in meristen cells of onion root tips; dinitrophenol (DNP) potentiates this caffeine effect. These effects suggest that caffeine could act as a negative, and some adenosine derivatives as a positive, effector on some enzyme(s) essentially involved in cytokinesis. We postulate that caffeine can block cell plate formation by inhibition of a certain ATPase activity essential for membrane fusion of Golgi vesicles. A general mechanism which could explain many of the biological effects of methyloxypurines is proposed.
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