Abstract
We have previously reported a reduced plasma triacylglycerol (TAG) concentration in elderly individuals following chronic intake of amino acids (AAs). To test whether acute intake of AAs increases fatty acid oxidation we compared 13CO2 breath enrichment from 5 elderly hypertriacylglycerolaemic volunteers (mean ± standard deviation (SD): age 66.0 ± 2.9 years; height 1.66 ± 0.04 m; body mass 85.5 ± 19.3 kg; BMI 28.8 ± 6.0 kg·m−2; fasting TAG 192 ± 46 mg·dl−1) during a basal period and a period of acute AA intake, whilst the participants were undergoing a constant infusion of U‐13C16‐palmitate. Participants received a drink containing 1 g of AAs every 10 minutes during the AA period, with 4 breath samples collected, 10 minutes apart, from 1 h 55 min to 2 h 25 min during each period. 13CO2/12CO2 ratio was determined using isotope ratio mass spectrometry. 13C breath enrichment was found to be significantly higher during the AA intake period than during the basal period (mean ± SD: atom % excess 0.22 ± 0.02 vs. 0.09 ± 0.01; P < 0.001). We conclude that acute amino acid intake increases fatty acid oxidation and may constitute a mechanism that contributes to lowering of the plasma TAG concentration. The study is sponsored by 1R01 AG033761 NIH/NIA. Screenings and study visits are being undertaken within the ITS‐Clinical Research Center at UTMB, Galveston, which is funded by grant 1 U54RR026141 from NIH/NCRR.
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