Abstract
The effects of actinomycin D on the development of odontogenic tissues were studied in the mandibular incisor teeth of rats. Morphologically, there was no evidence that actinomycin D interfered with the differentiation of ameloblasts nor with the functions of the enamel organ. In the pulpal tissues, the principal changes observed were necrosis of germinal cells, oedema throughout the apical areas, formation of dentine niches and production of osteodentine within the niches. Cytotoxic effects occurred only in cells which were beginning to differentiate towards odontoblasts, The anterior and posterior limits of these effects were sharply defined.
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