Abstract
The plasma concentrations of 17α-hydroxyprogesterone (17αOHP) and 17α'20α-dihydroxy-4-pregnen-3-one (17α20αOHP) have been measured in sheep during 5 days of ACTH administration at 20 μg/kg/day a rate of infusion known to produce hypertension. Five days of ACTH administration produced a progressive increase in plasma 170HP from 0.45 ± 0.12 to 128.9 ± 28.4 nmol/l and in 17α20αOHP from 0.54 ±0.15 to 73.1 ± 7.2 nmol/l. Calculation of the blood production rate of both steroids during ACTH treatment confirms that the rates of infusion of 170HP (3.0 μmol/h) and 17α20αOHP (1.5 μmol/h) used to produce hypertension, when infused together with the other major ovine adrenocortical steroids, produced plasma concentrations in the range as found following administration at a rate to increase blood pressure.
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