The effect of a stress upon the glycosuria of partially depancreatized force-fed rats.

Abstract

The hypothesis that any severe stress should intensify diabetes by activating the adrenal cortices is based upon the following observations: 1. The secretory activity of the adrenal cortices is increased during most if not all types of stress (Sayers and Sayers, 1948); 2. Adrenal cortex extracts and steroids are diabetogenic (Long, Katzin and Fry, 1940) and 3. Activation of the adrenal cortices by the administration of adrenocorticotrophic hormone intensifies diabetes (Ingle, Prestrud and Li, 1948). In the present study, the injection of dilute solutions of formaldehyde was used as a stress to partially depancreatized, force-fed rats. In moderately diabetic rats, the administration of formaldehyde was followed by some decrease in the levels of glycosuria in all of the animals. Injections of formaldehyde did not affect the level of glycosuria in severely diabetic rats. methods Male rats of the Sprague-Dawley strain of approximately 300 gm. were subjected to partial pancreatectomy by the technique of Ingle ...