Abstract
The effects of a single large dose (350 mg/kg) of cyclophosphamide on erythropoiesis and iron metabolism was studied in BALB/ep mice. These effects include erythropoietic depression lasting 7–10 days followed by a phase of recovery. The depressant action of the drug on erythrocyte production is accompanied by other metabolic effects on iron and hemoglobin metabolism.The erythroid aplasia develops faster and is more profound in spleen than in bone marrow. Radioactive iron injected 8 h after cyclophosphamide is cleared by bone marrow and liver with values above normal and released very slowly. These effects were not observed in the spleen. Differences in iron handling among the diverse sectors of iron stores suggest interference by this drug on the mechanism of hemoglobin breakdown and iron metabolism and an inhomogeneity of the reticuloendothelial system.
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