Abstract
Background: The study aimed to examine the effect of administering CHAGURO (a product of the combination of siamese pumpkin and tuna-based powder) on the lipid profile in prediabetes individuals with dyslipidemia. Methods: The experimental trial was conducted with two intervention groups, with each group receiving a dose of 7.5g/70kg body weight (BW)/day (low dose) and 15g/70kg BW/day (high dose) for 60 days. Respondents were randomized into intervention groups using simple randomization. Before and after the intervention, pre-test and post-test examinations were performed, factors examined included hemoglobin A1c (HbA1c), lipid profile, blood pressure, eating intake with the SQ-FFQ (Semi Quantitative-Food Frequency Questionnaire) interview, body mass index (BMI), and physical activity using InternationalPhysical Activity Questionnaires-Short Form (IPAQ-SF). During the intervention, blood pressure and BMI data were taken before and after the study. Statistical analysis included descriptive tests, independent and paired T-tests, and analysis of variance (ANOVA). Results: Compared to the baseline, HbA1c, total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides in the two groups did not improve significantly by 60 days. For lipid variables, a significant improvement in the cholesterol/high-density lipoprotein (chol/HDL) ratios were observed when compared against the baseline for the two groups. When comparing the changes between groups, 7.5 g of CHAGURO showed a larger improvement in HDL-C (mean differences: 1.86 mg/dL; 95% CI: -0.86-4.59), compared to 15 g of CHAGURO (mean differences: -3.62 mg/dL; 95% CI: -7.53-0.28). A significant (p<0.05) decrease in the chol/HDL ratio was observed in the 7.5 g CHAGURO group (mean differences: -0.20 mg/dL; 95% CI: -0.39-(-0.01)). Conclusions: CHAGURO can be a functional food alternative to improve the condition of prediabetes people with dyslipidemia. Trial registration: Dr. Sardjito General Hospital (KE/FK/0951/EC/2020), 27/08/2020
Highlights
Prediabetes is a condition that initiates the incidence of diabetes mellitus (DM), and its prevalence continues to increase.[1]
It can be concluded that the combination of siamese pumpkin and tuna has nutritional content that has the potential to improve the lipid profile and blood glucose so that it is protective against cardiovascular disease and type 2 DM
The study aimed to examine the effect of administering CHAGURO on serum levels of hemoglobin A1c (HbA1c), highdensity lipoprotein cholesterol (HDL-C), and cholesterol/high-density lipoprotein ratio in prediabetes individuals with dyslipidemia
Summary
1. Nurpudji Astuti Taslim , Hasanuddin University, Makassar, Indonesia Fahrul Nurkolis , State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga Yogyakarta), Yogyakarta, Indonesia Nelly Mayulu , Sam Ratulangi University, Manado, Indonesia. CHAGURO showed a larger improvement in HDL-C (mean differences: 1.86 mg/dL; 95% CI: -0.86-4.59), compared to 15 g of CHAGURO (mean differences: -3.62 mg/dL; 95% CI: -7.53-0.28). A significant (p
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