Abstract
The aim of this study was to evaluate the effect of platelet-rich fibrin (PRF), placed in extraction sockets, on bone regeneration and orthodontic tooth movement in adolescents. Fourty extraction sockets from twenty patients requiring extraction of first premolars based on their orthodontic treatment plan participated in this split-mouth clinical trial. Immediately, the teeth adjacent to the defects were pulled together by a NiTi closed-coil spring with constant force. The bone regeneration and the amount of orthodontic tooth movement was evaluated.
Highlights
Regenerative oral medicine entails the replacement of tissues lost to disease or injury with physiologically equivalent engineered tissues[1]
Recent approaches favor complex natural scaffolds that allow for repopulation with the patient’s own cells, thereby producing an autologous tissue-engineered organ [4]. One such complex natural scaffold ideally suited for autologous tissue regeneration is platelet-rich fibrin (PRF) is a second generation platelet containing biomaterial with potential applications in wound healing
PRF predominantly consists of a fibrin matrix rich in platelet and leukocyte cytokines such as IL-1, -4, -6, and growth factors such as Transforming Growth Factor beta 1 (TGF-β1), Platelet Derived Growth Factor (PDGF), and Vascular Endothelial Growth Factor (VEGF) [1]
Summary
Regenerative oral medicine entails the replacement of tissues lost to disease or injury with physiologically equivalent engineered tissues[1]. Tissues from the oral cavity are of complex nature with bordering mineralized and soft tissue components, both of which harbor unique progenitor populations residing within specialized extracellular matrix frameworks [2, 3]. Mimicking such complex environments by using chemically homogenous scaffolds and uniform stem cell populations is often challenging. Recent approaches favor complex natural scaffolds that allow for repopulation with the patient’s own cells, thereby producing an autologous tissue-engineered organ [4] One such complex natural scaffold ideally suited for autologous tissue regeneration is platelet-rich fibrin (PRF) is a second generation platelet containing biomaterial with potential applications in wound healing. This study sought to evaluate whether PRF application can accelerate bone regeneration ant orthodontic tooth movement
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